Verified Samples in WB:Mouse placenta,Rat placenta
Verified Samples in IHC:Human placenta

WB 1:500-1:1000;IHC 1:400-1:800

Polyclonal

IgG

Recombinant Human HTRA1 protein expressed by E.coli

HTRA1

Serine protease HTRA1; High-temperature requirement A serine peptidase 1; L56; Serine protease 11; PRSS11

51 kDa

51 kDa

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide, 50% glycerol, pH 7.4

Affinity purification

Cancer; Signal transduction

Unconjugated

Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.