ELISA 2-8mg/mL(Cap),0.1-0.4mg/mL(Det)

Polyclonal

Rabbit IgG

Recombinant Human PPY Protein expressed by E.coli

PPY

Pancreatic polypeptide prohormone;PH;Pancreatic polypeptide Y;Pancreatic polypeptide;Pancreatic icosapeptide;PPY;PNP

1mg/mL

Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide,pH 7.4

Antigen Affinity Purification

Signal Transduction

Unconjugated

Pancreatic polypeptide (PP),36-amino acid peptide,may function as an important feedback inhibitor of pancreatic secretion after a meal. It arises from both islet and acinar cells of the pancreas. Release of PP by a meal,primarily protein,occurs in a biphasic manner. PP is a negative regulator of energy homeostasis that suppresses food intake and lowers body weight. Similar to other gastrointestinal-derived peptides,PP also modulates gastrointestinal motility and may be involved in the regulation of anxiety. PP,a robust anorexigenic hormone,effectively modulates food intake and energy homeostasis,thus potentially aiding anti-obesity therapeutics. PP is produced in pancreatic islets of Langerhans and released into the circulation after ingestion of a meal. Peripherally administered PP suppresses food intake and gastric emptying. On the other hand,central administration of PP elicits food intake and gastric emptying.